Pycnogenol

2025-02-20:

Pycnogenol®/Oligopin® (Maritime pine bark extract) #

Pretty sure it’s the same name. Maritine = pinus pinaster, not Pinus massoniana.

• Extract made to be rich in proCyanidins (70% to be exact) and proAnthocyanin. Grape seed extract has a very similar mix of procyanidin/proanthocyanidins. Kinda interchangeable.
• It’s mainly an antiinflammatory:
  • NF-κB inhibition, AMPK activation
  • MMP inhibition
  • Thromboxane A2 downregulation; increases PGI2.
  • PPAR-γ.
• Mild Aromatase inhibitor Grape Seed Extract Is an Aromatase Inhibitor and a Suppressor of Aromatase Expression
• Pycnogenol® improves cognitive function, attention, mental performance and specific professional skills in healthy professionals aged 35-55
  • … in combination with a health plan.
• Kuja says that it’s oddly one of the only non-stimulant things that helps with (his) ADHD.
  • The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD) GSH up.
  • Effect of polyphenolic extract, Pycnogenol, on the level of 8-oxoguanine in children suffering from attention deficit/hyperactivity disorder 8-oxoG = oxidized purine biomarker, and is inversely related to the total antioxidant status. TAS is lower in ADHD and was increased after Pyc and 1 month after Pyc
• People take it for blood flow, but it might be cope: Effect of Pycnogenol on Blood Pressure: Findings From a PRISMA Compliant Systematic Review and Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled, Clinical Studies no significant effect on blood pressure
• Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidase
  • I have a feeling α-Glucosidase inhibition is probably a bad thing; glucose disposal type shit
• An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study

Dose #

CityWok became a schizo about it. Üxkull put it on the top 3 supplements for skin aging next to tretinoin and GHK-Cu so god mothafuckin damn. I think 50-100mg is the dose. It becomes intolerable in high doses for reasons I am yet to discover