Methylation

links: reference: 8-18-2021

Methylation #

• Undermethylation $\approx$ histadelia. Caused by lack of methionine, choline, betaine, homocysteine, B12, B9, B2, B3, B6, Zinc. Overmethylation corresponds to higher norepinephrine, while undermethylation has a more dopaminergic tone.

  • How to induce undermethylation? With methyl traps like Cyano/hydroxy/adenosyl-B12, Folate, glutahione, cysteine, and restriction of stuff like methionine.

• https://chrismasterjohnphd.com/blog/2019/03/01/start-here-for-mthfr-and-methylation

  • Methylation helps rid of histamine.
  • Overmethylation can lead to ADHD-like symptoms due to being so mentally flexible.
  • Methylation consumes Glycine; it is the buffer. Consuming more in the case of excess is better than increasing B3, as glycine is a buffer, whereas niacinamide can bring one to undermethylation.

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• Supposedly 40-45% is used to make creatine, and another 40-45% for phosphatidylcholine.

• Undermethylation is an effect of aging. Transsulfuration increases with oxidative stress, but that’s not a reason to avoid the pathway. R

• Hypermethylation could lead to excess conversion of dopamine to Noradrenaline.

• CMJ: Undermethylation = physical tiredness bourne of the mind; overmethylation = mental tiredness bourne of the body.

• Terma: Consume all your methyl groups and most of your protein at dinner time, since that Kennedy pathway activity might put a burden on Phosphatidylcholine production for Bile during the day.