Methionine

links: Amino Acid reference: https://acidicbody.com/histamine-toxicity-high-histamine/ 4-20-2021

Methionine #

• Once it donates its methyl group, methionine becomes Homocysteine.
• Anti-folate, adding a methyl group to help histamine mobilization.
• As a methyl donor, it is used to create polyamines, Creatine, and Phosphatidylcholine.
• Readily

Restriction #

• Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms - in obese, prediabetic mice.
  • Induces energy expenditure -> lean mass & metabolic health via inducing FGF21-UCP1 axis, and only in males.
• The most lifespan-decreasing amino acid, followed by Tryptophan.
  • Low methionine ingestion extends lifespan.
  • Methionine restriction increases blood glutathione and longevity in F344 rats
    • All changes occured 2 months after starting the diet. 0.17% methionine and 3.39% glutamic acid, control being 0.86 met and 2.70% glu.
    • Restricting methionine in rats resulted in 44% increase in lifespan
    • Increased blood levels of 81% mature rats and 164% for elderly. Reduced hepatic Glutathione by 40%, and 25 decrease in kidney.
• Implementation of dietary methionine restriction using casein after selective, oxidative deletion of methionine
  • Methionine is readily degraded to methionine sulfoxide by H2O2.
• Toxicity of Various Organic Sulfur Compounds for Chicks Fed Crystalline Amino Acid Diets Containing Threonine and Glycine at Their Minimal Dietary Requirements for Maximal Growth
  • An excess can suppress growth. Glycine can reverse this.