PGC-1α
2022-05-08: reference:
PGC-1α (PPAR-γ coactivator 1α) #
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A master regulator of expression of mitochondrial Antioxidant genes and mitochondrial biogenesis.
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Induced by cold exposure, CREB, PKA, fasting. I think it’s induced by ROS as well.
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Induced by endurance exercise
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Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A
- The idea is to make lactate more efficient of an energy source.
- Elevated PGC-1α expression = mimics an endurance-trained phenotype; a shift from fast, glycolytic towards slow, oxidative fibers, including slow fiber type-specific calcium signaling.
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Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A
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Induced by mTOR: Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium
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Inhibited by the TrkB cascade.
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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
- PGC-1α potently induced Fatty Acid Oxidation that was blocked by expression of GCN5, or Nicotinamide treatment
- https://raypeatforum.com/community/threads/niacinamide-lowers-fatty-acid-oxidation-by-inhibiting-sirt1.3421/#post-82720