Taurine

4-13-2021 links: Nootropics Amino Acid reference:

• Taurine Induces a Long-Lasting Increase of Synaptic Efficacy and Axon Excitability in the Hippocampus

Taurine #

Taurine is an abundant amino acid found throughout the body, but especially saturates in tissues containing excitable cells, such as nerves or heart muscle.

• (Taurine transporter: SLC6A6)

• Taurine enhances the sexual response and mating ability in aged male rats

  • Increases Gonadotropin-releasing Hormone, Luteinizing Hormone, and Testosterone

• The effect of taurine on motor behaviour, body temperature and monoamine metabolism in rat brain

  • DOPA formation was significantly enhanced. Dopamine depletion induced by α-methyltyrosine (Tyrosine Hydroxylase inhibitor) was significantly retarded, whereas noradrenaline depletion was enhanced. (Does this indicate a preference for retention of DA?)
  • Increased endogenous levels of dopamine, whereas tyrosine, tyrptophan, noradrenaline, and 5-HT and 5-HIAA levels remained unchanged.
  • Causes inhibition of firing in central DA neurons [how? why?], but has the opposite effect on NA.

• Taurine diminished the apparent affinity of NMDAR to glycine in the presence of spermine. R

• "(100mg/kg/day p.o.) Taurine reversed nandrolone decanoate-induced perturbations in sperm characteristics, normalized serum testosterone level, and restored the activities of the key steroidogenic enzymes; 3β-HSD, and 17β-HSD." R

• Pharmacological characterization of GABAA receptors in taurine-fed mice

  • We reported that GABA-A receptors were down regulated with chronic administration of taurine

• Glycation inhibitor.

• Improves NO-mediated relaxations of corpus cavernosum in diabetics rats probably by inhibiting NADPH Oxidase/Rho kinase pathways. R

• Agonizes GABA-A. I think it increases Alpha waves

• Increases brain Acetylcholine

• Keeps the temperature stable, anti-inflammatory, keeps calcium balanced (flushes out excess), Antioxidant, Balances electrolytes, anxiolytic, lowers neuroinflammation, anti-diabetic, antiarrhythmic.

• Heals the Liver, activates autophagy, diuretic, protects against fluoride, increases BDNF, decreases cortisol.

• Supports heart health by regulating fibrosis and reducing oxidative stress and vascular resistance, and blocks sympathetic nerve activity.

• Is a component of Bile acid, so supports digestion and detoxification of that which is excreted through it, like Estrogen. This also increases cholesterol utilization.

• Inhibits Lactate Dehydrogenase

• Inhibits SREBP

• Increases LTP/neurogenesis in striatum/hippocampus (increases stem cells and progenitor cells)

• Membrane stabilization

• Protection against glutamate excitotoxicity (reduces intracellular free calcium and is an antioxidant)

• No effect on choline/phospholipid status, but increased taurine concentrations in tissues may affect oxidation status when methionine availability is low. R

  • I have stil heard it has anticholinergic properties though

Supplementation #

• 1-hour half life. Tissue saturation can be achieved for months but I’ll have to look into that