Protein Kinase B
2022-04-12: reference:
Protein Kinase B (AKT (Kinase)) #
It’s good stuff. Generally an antioxidant and inhibits naughty stuff.
When inactive, it binds to membrane PIP3. After being phosphorylated at Thr308 by PDK1 (which uses ATP), it dissociates:
- mTORC2 phosphorylates Ser473 is also required for full function. Unphosphorylated, some targets like TSC2 and GSK-3β remain unaffected, but other targets like FOXO are unable to be phosphorylated.