PDGF

2022-08-11: reference:

PDGF #

• Key for Blood Vessel formation.
  • In diabetic neuropathy, persistent activation of PKC and MAPK inhibits signaling throught PDGFR, leading to apoptosis of retinal cells. Something like that
• In acutely isolated rat hippocampal neurons, direct activation of the PDGFR or transactivation of PDGFR by D4 inhibits NMDA-evoked currents in a [Phospholipase C]-dependent manner.
• Receptor tyrosine kinase transactivation: fine-tuning synaptic transmission
  • Autophosphorylation leads to recruitment of Phospholipase Cγ, leading to IP3->Ca2+->Calmodulin. The Ca2+-dependent inactivation is somehow dependent on the state of polymerization of actin filaments in the PSD, not dependent on PI3K, CAMK II or PP2B.
  • And so through some cascade, D4 promotes this PDGF phosphorylation.
• Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons
  • Abelson kinase associates with PDGFβR, Phospholipase Cγ, and Src. After Abl is phosphorylated it dissociates and activates ROCK, which inhibits NMDAR currents via fucking up the actin cytoskeleton.
  • This is in acutely dissociated CA1 neurons but not in cultures.