FGF15

2022-01-12 links: reference:

FGF15/19 (Fibroblast Growth Factor 15/19) #

• Mainly exists in the ileum, and under circumstances liver and biliary tree.
• FGF5 inhibits hair growth by blocking dermal papilla activation
• Dysregulated fibroblast growth factor (FGF) signaling in neurological and psychiatric disorders
  • [Decreased levels of serum fibroblast growth factor-2 in children with autism spectrum disorder]( https://pubmed.ncbi.nlm.nih.gov/28734240/
• Binds to heparin and heparan sulfate.
• Induces expression of SHP (small heterodimer partner) -> inhibits bile secretion.
• FGF15 in mice, = 19 in humans. (Along with FGF21 and FGF23, they have systemic, hormonal effects.)