NGF
links: reference: 5-7-2021
Nerve Growth Factor #
- NGF can impair focus and decrease pain tolerance via upregulating calcium channel activity. This in turn increases Histamine.
- Binds to TrkA.
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Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurons in culture, and this effect requires activation of Gs-coupled excitatory κ-opioid receptors on these cells
- NGF-induced APD (action potential duration) prolongation is prevented by the opioid receptor antagonist naloxone and the specific κ-Opioid Receptor antagonist nor-binaltorphimine (but not by specific mu- and delta-opioid antagonists).
- The results suggest that NGF stimulates the release of endogenous opioids (e.g., dynorphin) from dorsal root ganglion neurons and that prolongation of the APD occurs secondarily by activation of excitatory kappa-opioid receptor functions on these same or nearby cells.
- NGF-induced APD (action potential duration) prolongation is prevented by the opioid receptor antagonist naloxone and the specific κ-Opioid Receptor antagonist nor-binaltorphimine (but not by specific mu- and delta-opioid antagonists).
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Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex
- Mediates innervation of cholinergic neurons during development, maintaining cholinergic corticopetal projections during adulthood and modulates cholinergic function through phenotypic control of the cholinergic gene locus.