Leptin

Inhibits hunger in order to regulate energy balance and diminish fat storage in Adipocytes. It is released when you are satiated.
Produced by adipose cells and Enterocytes in the small intestine.
Leptin receptor activates JAK2-STAT
One would improve leptin sensitivity basically the same way one would with insulin; basal levels are correlated with body fat.
- What are low levels of leptin (taking into account resistance; I reckon it has good homeostasis, or at least compared to insulin) = starvation mode/fasting, where appetite is increased and metabolism is decreased.
It speeds up the metabolism, increases thyroid hormon through by doing this
Leptin increases during sleep. Sleep deprivation lowers leptin and increases ghrelin.
Promotes Temperature, metabolism, and Steroidogenesis
Increases Tyrosine Hydroxylase in the Nucleus Accumbens R
Intracerebroventricular administration stimulates mTORC1 in the Arcuate Nucleus and reduces food intake. R
Increases Striatum D2 binding R

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