Mirtazapine

2022-02-08 links: Drugs reference:

• Crazy. Can’t say this wouldn’t be interesting. https://mad.science.blog/2021/11/12/remeron-the-dream-drug/
• A few papers

Mirtazapine #

Apparently not discussed too often in Lucid Dreaming communities but it ought to be. Also frequently used in bodybuilding. Blocks the effects of psychedelics.

• 5-HT2B inverse agonist, 5-HT2A 5-HT2C, and 5-HT3 antagonist.

• 5-HT1A agonist, and induced lower lip retraction in rats (characteristic of 5-HT1A - it’s kinda like smiling??) R

  • 5-HT1A agonism makes you eat carbs like a horse

• Increases serotonergic cell-firing in the dorsal raphe and 5-HT release in the hippocampus Explained by noradrenergic enhancement of 5-HT cell-firing and blockade of noradrenaline-mediated inhibition of hippocampal 5-HT release.

• κ-Opioid Receptor agonist.

• Associated with a significant increase in body weight, body fat mass, and Leptin concentration R… Insulin Resistance is associated with elevated plasma leptin levels independent of body fat mass.

  • Increases leptin ~2fold without desensitization.

• The plasma levels of TNF-α and both soluble TNF receptors increased. R

• 10mg/kg in rats (~111mg - absorption though? Perhaps poor oral) 1-2x/day for 14 days reduced by 50% the effect of stress on basal norepinephrine output. Acute administration of FG7142 (30 mg/kg, i.p.), an anxiogenic benzodiazepine receptor inverse agonist, induced a marked increase in norepinephrine output (+90%) in control rats. In rats chronically treated with imipramine or mirtazapine this effect was completely antagonized. R

• 5-week treatment with mirtazapine (45 mg/day) showed significant increases in Allopregnanolone, 3alpha,5beta-tetrahydroprogesterone, 5α-DHP, and 5β-DHP, after mirtazapine treatment, whereas 3beta,5alpha-tetrahydroprogesterone levels were significantly decreased.

  • 3,beta,5,alpha lacks GABA-A binding and neuroprotection.

• Acutely inhibits Cortisol secretion and Adrenocortocotropic Hormone release R

• Slight antiHistamine, like most antipsychotics, and then psychedelics are usually histamine liberators. Rleated?

• Antagonist of alpha 2 adrenoreceptors.

• olvive said: Powerful lowering of Cortisol, increase in neurosteroid production, gut motility, lipolyti, antidepressant, powerful enhancement in REM and sleep in general, and preference for carbs.

• Increases anxiety, irritability, and aggression at the beginning of treatment, but then clears. Gave a man edema.

• The antinociceptive effect of mirtazapine in mice is mediated through serotonergic, noradrenergic and opioid mechanisms

  • Mirtazapine (at 10 mg/kg)-induced antinociception was significantly inhibited by naloxone, nor-BNI

Supplementation #

7.5-15 mg sublinual before bed - more than that tends to be stimulatory.