5-HT2C
links: Serotonin Neuroreceptors reference: 4-30-2021
5-HT2C #
A GPCR.
- Activation by serotonin inhibits dopamine and noradrenaline release in certain areas of the brain, like the frontal cortex. (wherever they may be.)
- Regulates dopamine release in the striatum, prefrontal cortex, nucleus accumbens, hippocampus, hypothalamus, amygdala, and more.
- SSRIs (at least some of them) end up downregulating it.
- Increases Corticotrophin-releasing hormone and thus Proopiomelanocortin; this is Serotonin’s gateway to raising cortisol.
- Increases Vasopressin mRNA in paraventricular nucleus.
- Some suicide victims have an abnormally high number of 5-HT2C receptors in the prefrontal crotex.
- Implicated in nightmares
- 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion