Lisuride

links: Drugs reference: 9-19-2021

Lisuride #

‘A non-hallucinogenic congener of LSD’.

• Treats high Prolactin, as it is a Dopamine agonist - one of the most potent in clinical/research use.

  • Active on D1 and D5, and a good deal less on D2, D3, and D4.
    • D3 antagonized at 8 nM/L, which is like 1.25mg?
      • https://raypeatforum.com/community/threads/lisuride-liquid-lisuride-for-lab-r-d.12099/post-216361
  • Effective as Bromocriptine for hyperprolactinemia, and lasts longer.
    • http://www.ncbi.nlm.nih.gov/pubmed/3566845

• An “inactive” antagonist of 5-HT2B (unlike other ergot derivatives) 5-HT6, and 5-HT7. It renders them unable to react to agonists, and this effect lasts a very long time, after lisuride is excreted from the body.

  • Antagonist of 5-HT2A; explains its antagonism to LSD hallucinogenic effects?
    • “Agonist activity of LSD and lisquride at cloned 5HT2A and 5HT2C receptors” https://pubmed.ncbi.nlm.nih.gov/9600588/
      • Potent antagonist of 5-HT2C (Maybe agonist? Fuck this).
        • Agonism can mimic the effect of light pulses on the circadian rhythm. 5-HT7 also has impications in that.
          • https://raypeatforum.com/community/threads/lisuride-liquid-lisuride-for-lab-r-d.12099/post-325494

• On idealabs (.025mg/drop x 240): https://raypeatforum.com/community/threads/lisuride-liquid-lisuride-for-lab-r-d.12099/

  • Lasts 3+ months. In DMSO probably longer. It has lasted 9 months for people.
  • Compared to Ritanserin, lisuride is a much more potent dopamine agonist and less of a serotonin antagonist.
  • Can lead to dopamine agonist withdrawal syndrome (DAWS) when used in high doses and/or for several months. Recovery can take months to years, or never. Therefore, cycle it or die. Haidut claims he has never seen DAWS reported from Lisuride, though. (Pg. 25). The ergot derivatives are also the least risky compared to newer dopamine agonists.
  • Only ergot derivative devoid of fibrosis side effects, and it can possibly reverse them.
  • Clears congestion
  • Its half life is about 6 hours, but the effects last much longer, possibly explained by slow tissue metabolism.
  • All ergot derivatives, besides metergoline and methysergide, can cause serotonin syndrome when combined with SSRI or MAO-A inhibitors.
  • Haidut has not found any negative effect on steroidogenesis from dopamine agonists.
  • Increased Testosterone in hyperprolactinemic patients by 86%. R

• White FJ. Comparative effects of LSD and Lisuride…

  • Like LSD, decreases 5-HIAA.
  • Decreases synthesis and metabolism of Serotonin.
  • Increases Noradrenaline turnover.
  • Stronger Dopamine agonist than LSD.
  • Decreases DOPA accumulation in DA-rich brain regions.
  • Reduces concentrations of Homovanillic Acid

• https://raypeatforum.com/community/threads/lisuride-liquid-lisuride-for-lab-r-d.12099/post-170327

  • List of all its binding affinities.

• Binds to non-heteromized 5-HT2A. This makes it a competitive antagonist to hallucinogens that bind to 5-HT2A.

  • Wait but what about mGluR2 heteromers?? Like that caveat specifically would make it confusing I gotta find a source

• Agonist of 5-HT1A and 5-HT2C.

• Histamine antagonist on H1 and H2.

• Sides effects: nausea, decreased Blood Pressure. Haidut says metergoline doesn’t cause nausea, unlike lisuride.

Supplementation #

0.1-0.6-2mg. 0.2mg is probably good. But there are studies with a 4mg daily dose. It’s contentious whether you should take it in the morning or evening, but it knocks a lot of people out. People are saying that after a few days, the lethargy goes away.