mGluR2

links: Neuroreceptors mGluR Glutamate reference: 11-4-2021

Metabotropic glutamate receptor 2 (mGluR2) #

• Glutamate autoreceptor. Inhibits the emptying of vesiular contents at the presynaptic terminal of glutamatergic neurons, but is also expressed postsynaptically.
• Rapamycin blocks the antidepressant effects of its inhibition (by LY379268) in the forced swim test
• Anticognitive. Sirsad said when it isn’t inhibited, LTP literally can’t even form, and learning is abolished. mGluR2 inhibition:
  • Mediates the cognition enhancement by Aldosterone, which is demonstrated to elevate cognition in healthy people, and is a limiting factor in the cognition enhancement by AMPA PAMs which are the most well documented nootropics
    • Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility
    • “Why do some individuals succumb to stress and develop debilitating psychiatric disorders, whereas others adapt well in the face of adversity?”: mGluR2 is a marker of individual differences to stress-induced mood disorders. genetic mGlu2 deletion in mice results in a more severe susceptibility to stress, mimicking the susceptible mouse sub-population.
    • Mineralcorticoid receptor agonists downregulate mGluR2, decreasing stress resilience.
  • Likewise, improves cognition in preclinical studies
  • Has strong antidepressant effects in preclinical studies
  • Produces a neuroprotective effect in some preclinical studies
  • Mediates the effects of psychedelics
    • [Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists](Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists)
  • NAM might be more effective. Something like VU6001966