Catecholamine

4-12-2021 links: reference:

Catecholamines #

Subtype of the Monoamine. They are: Dopamine Noradrenaline and Adrenaline. Organic compiunds with a catechol (benzene with two hydroxyl (OH) side groups next to eachother) and then a side-chain Amine.

Biosynthesis #

Made in the Medulla. Derived from Tyrosine and Phenylalanine

• &

1. Phenylalanine $\ce{->[Phenylalanine Hydroxylase] }$ Tyrosine
   • Cofactors: P5P, Iron, BH4; Vitamin C, 5-MTHF, B3
2. Tyrosine $\ce{->[Tyrosine Hydroxylase] }$ DOPA
   • Cofactors: P5P, Iron, BH4, and Vitamin D
3. DOPA $\ce{->[Aromatic L-Amino Acid Decarboxylase] }$ Dopamine
   • Cofactors: P5P
4. Dopamine $\ce{->[Dopamine β-Hydroxlyase] }$ Noradrenaline
   • Cofactors: Vitamin C, Copper, B3
5. Noradrenaline $\ce{->[PEMT] }$ Adrenaline
   • Cofactors: SAM-e, Cortisol