COMT

links: Enzyme reference: https://men-elite.com/2019/02/08/reduce-estrogen-12-best-ways/ 4-24-2021

Catechol-O-Methyltransferase (COMT) #

• Deactivates via the addition of a methyl group (taken from SAM-e):
  • Catecholamines
    • CMJ: Low COMT = focus on tasks for a long time; OCD phenotype. High COMT = low tonic Dopamine, such that phasic bursts look bigger = easy/excessive task switching.
  • Catechol Estrogens into 2-methoxy derivatives, i.e. 2-Methoxyestradiol
    • Travis: The methoxy-estrogens are the most poweful endogenous Microtubule depolymerizing agents known. R
      • And cytoskeletal integrity is of high importance in cancer proliferation; the entire cytoskeleton needs to be dissembled before mitosis can occur.
      • Estradiol → FASN and Δ9 Desaturase → swelling the cell membrane with the more fluid Oleic Acid, so that the cell can divide.
  • … and whatever drugs/substances with a catechol structure. Magnesium is a cofactor.
• 
  • Lower COMT activity = greater processing of emotional stimuli to compensate (via [Orbitofrontal Cortex-Amygdala functional connectivity.])