SERT
links: reference: 6-29-2021
SERT (5-HTT) (SLC6A4) #
- The Sodium-dependent Serotonin transporter protein, and it transports serotonin from the synaptic cleft back to the presynaptic neuron.
- It is the primary target of SSRI - for they inhibit its function.
- Correlation between Cortisol level and serotonin uptake; cortisol acutely increases SERT RPF
- IFN-γ and TNF-α decrease serotonin transporter function and expression in Caco2 cells
- Making Pyramidal Neurons express SERT with gene insertion gives them a bunch of neuroplasticity, since they can start activating intracellular 5-HT2A