Kaempferol

2022-08-17: reference:

Kaempferol #

• Flavonol, Phytoestrogen, mutagen. Epidemiological studies have shown an inverse relationship between kaempferol intake and cancer.
• Inhibits Src, Fatty Acid Synthase, HIF-1α, AKT, ESRRA, cMyc.but binds to GLUT4 and inhibits its function. NAUGHTY!! but:
• The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.
  • 2-20 μM.
  • (Deiodinase II)
    • So other Flavonols are looking pro-thyroid.
      • … This indicates that the presence of an OH group at position C‐#3 negatively correlates with T4‐Deiodinase stimulating potency within the flavonol group (Catechin for example has this)
    • 3x upregulation of Deiodinase II and dramatic increase in its half-life, making DII activity ~10x, with a concurrent 2.6x increase in T3 production!!
  • Activates cAMP->PKA.
  • Treatment with KPF leads to an approximately 30% increase in skeletal myocyte oxygen consumption
• Inhibition of 17 beta-estradiol metabolism by grapefruit juice in ovariectomized women
  • It increases bioavailability of Estrone and Estradiol and has great affinity for estrogen receptor binding.

Foods #

• Garlic (somewhere in here) capers, raw 259 saffron 205 capers, canned 131 arugula, raw 59 kale, raw 47 mustard greens, raw 38 Ginger 34 common bean, raw 26 chinese cabbage, raw 23 dill, fresh 13 garden cress, raw 13 chive, raw 10 dock, raw 10 endive, raw 10 collard, raw 9 broccoli, raw 8 fennel leaves 7 goji berry, dried 6