Fatty Acid Synthase
links: Enzyme reference: 4-23-2021
Fatty Acid Synthase #
Catalyzes fatty acid synthesis. Uses NADPH as a cofactor.
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- Knockdown of FASN using RNA interference drasticaly lowered (>100x) the amount of Estradiol required for activation of ERα-mediated transcriptional activity.
- FASN blockased synergistically increased E2-stimulated ERα-mediated transcriptional activity in ERα-negative breast cancer cells stably transfected with ERα, but not in ERα-negative parental cells.