VMAT2
2022-02-04 links: reference: https://www.reddit.com/r/Nootropics/comments/qqrhrc/the_importance_of_vmat2_in_the_prevention_of/
VMAT2 (SLC18A2) #
- An integral memrane protein (IMP). Catalyzes transport of Monoamines from the cytosol into synaptic vesicles via exporting 2 H+.
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- Dopaminergic neurons inhibit striatal output via non-canonical release of GABA apparently required for GABA release.
- Amphetamine binds to its ‘TBZ (tetrabenzanine) binding site’, and methamphetamine binds to its ‘reserpine binding site’.
- Cocaine-induced mood disorders display significant loss of VMAT2 immunoreactivity.
- https://www.geneticlifehacks.com/vmat2-gene-the-god-gene-and-neurotransmitters/ - pretty sure the whole ‘god gene’ thing is based off a single study.
- [Synaptic Vesicle Transporter Expression Regulates Vesicle Phenotype and Quantal Size]
- Loss of Striatal Vesicular Monoamine Transporter Protein (VMAT2) in Human Cocaine Users
- Increased Vesicular Monoamine Transporter Binding during Early Abstinence In Human Methamphetamine Users: Is VMAT2 a Stable Dopamine Neuron Biomarker?