mGluR

2022-01-12 links: reference:

mGluR #

Metabotropic Glutamate receptors.

• Group I (Gαq): Increases NMDAR activity
  • mGluR1: enhances excitability, plasticity; LTP/LTD
    • Primarily postsynaptic.
  • mGluR5: elevates intracellular calcium
    • Primarily postsynaptic, and Astrocyte
• Group II (Gαi):
  • mGluR2: inhibit presynaptic glutamate; LTP
    • Mainly presynaptic.
    • mGluR2 postsynaptically senses granule cell inputs at Golgi cell synapses
  • mGluR3: inhibits cystine/glutamate antiporter
    • Mainly presynaptic. In dlPFC layer III, it is concentrated postsynapitcally. (and mGluR2 still mainly presynaptic with a minor postsynaptic component)
    • The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations
• Group III (Gαi):
  • mGluR4 (Primarily presynaptic),
  • mGluR6 (retinal).
    • Postsynaptic.
  • mGluR7 and mGluR8 (both): increases glutamate uptake