mGluR5
2022-12-03:
mGluR5 #
- Gq
- Upregulated in astrocytes by Aβ
-
Inhibition of the ISR abrogates mGluR5-dependent long-term depression and spatial memory deficits in a rat model of Alzheimer’s disease ISRIB
- Increasing eIF2α phosphorylation, the core event of ISR, facilitates metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD),