JNK
2022-04-19: reference:
JNK (c-Jun N-terminal kinases) #
Stress stimulates its production. Activates TNF-α.
- Activation is ultimately carried out by MKK7 and MKK4.
- Downstream molecules that are activated by JNK include: c-Jun, ATF2, ELK1, SMAD4, p53 and HSF1
- JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory