WISP1
2022-07-06: reference:
WISP1 (Wnt1 inducible signaling pathway protein 1) #
- WISP1 is expressed in the epithelium, heart, kidney, lung, pancreas, placenta, ovaries, small intestine, and spleen with limited brain expression
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Wnt1 Inducible Signaling Pathway Protein 1 (WISP1) Blocks Neurodegeneration through Phosphoinositide 3 Kinase/Akt1 and Apoptotic Mitochondrial Signaling Involving Bad, Bax, Bim, and Bcl-xL
- Phosphorylation of Bad, GSK-3β, minimizing expression of Bim/BAX->Caspase 3 and Cytochrome C release, and Mitochondria membrane permeability.
- Indeed, WNT-dependent neuroprotection requires p-AKT. Gene silencing of AKT eliminates capacity of WNT1 to prevent apoptosis. R
- Phosphorylation of Bad, GSK-3β, minimizing expression of Bim/BAX->Caspase 3 and Cytochrome C release, and Mitochondria membrane permeability.
- WISP1 by decreasing phosphorlation of TSC2 Ser1387 and increasing Thr1462, a target of AKT.
- Promotes nuclear trafficking of SIRT1.