yana-notes

Uridine

links: Nucleoside reference: 8-24-2021

Uridine 120 #

Udine Monophosphate #

https://www.ncbi.nlm.nih.gov/pubmed/2906500 I think overall it’s antidopaminergic.

  • May promote memory/learning, Neurogenesis

  • May improve motivation/attention

  • Increases secretion of Insulin

  • May decrease bone density

  • Uridine significantly increases potassium-evoked Dopamine release in striatal cells R R R Also increases D2R turnover.

  • Does it upregulate or downregulate dopamine?

    • Decreases the density of striatal D2 receptors, and at the same time, increases DA-dependent behavioral scores during recovery from injection of EEDQ (dopamine antagonist.)
      • This discrepancy may be explained by the assumption that (maybe?) many D2 antagonist binding sites represent spare receptors, not functional ones. (This is from the same paper)

  • Emotion-dampening

  • With alpha-synuclein, it ‘inhibits consciousness’ in the cerebral cortex (and CNS activity) by inducing changes in neuronal excitability and antagonizing dopamine and mitochondrial function.

  • Stimulates NGF

  • Monomer of RNA; increases synthesis of cellular membranes.

  • Elevates Phosphatidylcholine: component of dendritic membranes

  • Plays a role as a substrate in Phosphatidylcholine synthesis, through the CDP choline pathway (the Kennedy cycle): synthesizing phosphatidylethanolamine, which contributes to building brain cell membranes and plays a huge role in neurotransmission.

    • Therefore, it increases consumption of Choline.

  • Increases dendritic spines (neurogenesis)

  • Possible GABA agonist

  • Fasting causes an adipocyte-mediated rise in plasma uridine, which triggers a lowering of body temperature. Feeding causes a bile-mediated drop in plasma uridine, which enhances insulin sensitivity in a leptin-dependent manner. Thus, uridine is part of a complex regulatory loop that affects energy balance and potentially contributes to metabolic disease.

    • This temperature drop was attenuated with a prolonged exposure to a high-fat diet (in mice?)

  • Improved mitochondrial function in bipolar adolescents.

  • Lowers nerve pain

  • Protects against lung disease

  • Promotes Slow-wave sleep

  • Some people experience insomnia. It seems that if one does not get tired, morning/afternoonis probably preferable to experience the full range of effects. Half-life is something like 8 hours.

Supplementation #

Backlinks

Interactive Graph