Phosphatidylcholine

links: reference: Phospholipid 8-18-2021

Phosphatidylcholine #

(PtdCo connected to C16 and C18)

• An elevation can enhance athletic performance, and can convert to Phosphatidic Acid, which has an anabolic effect.

• TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells

• Secretion of PC in Bile is cytoprotective to the biliary and mucosal epithelium. It enhances micellar solubilization of biliary cholesterol, the emulgation of the dietary triacylglycerols, and the micellar solubilization of the lipolysis products. R

• Dietary Phospholipids and Intestinal Cholesterol Absorption

  • Mitolipin: 600 IU vitamin E per serving/15 per drop. It does not contain policosanol like tocovit - but perhaps the tocopherols are comparable?
  • The predominant phospholipid in the lumen is PC, the second most abundant lipid after triglyceride. Synthesis from Bile amounts to ~10-20g PC and ~1.5g of cholesterol per day.

• Its sratio with Phosphatidylethanolamine is relevant:

  • Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans
    • total muscle PC and PE are positively related to insulin sensitivity while PC:PE ratio is inversely related to insulin sensitivity in humans
  • The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis
  • Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine

• Effects of Linoleic Acid Position in Phosphatidylcholines and Cholesterol Addition on Their Rates of Peroxidation in Unilamellar Liposomes

  • Our results indicate that cholesterol in PLPC and LPPC liposomes inhibited Lipid Peroxidation in a dose-dependent manner when initiated by AAPH
  • The linoleoyl moiety at sn-1 (the closer carbonyl to the hydrophilic head) was less sensitive than that at the sn-2 to aqueous radicals.

• Unlike Glycerophosphocholine or Choline Chloride, Dietary Phosphatidylcholine Does Not Increase Plasma Trimethylamine-N-Oxide Levels in Sprague-Dawley Rats

Supplementation #

• 15% choline by weight.
• Mitolipin: $40 for 6g PC (150mg/ $) (900mg Ch = 22.5mg/ $)
• https://bodybio.com/products/bodybio-pc-phosphatidylcholine
  • https://www.youtube.com/watch?v=bGrux8nymg0 These people claim that non-liposomal PC, i.e. lecithin, is not bioavailable.
• Change the weight or no? Because per teaspoon it’s 3g, while for other brands it’s like 700mg per teaspoon. I also don’t know how to abstract the fat content.
  • The winner: https://nutrasal.com/products/phoschol-liquid-concentrate-8oz 3g/tsp (so 450mg choline + 3g fat (only 0.5 of which is PUFA)) = 722mg/$.
    • So 1.5g = 225mg choline.
  • Up to 52% dilinoleoylphosphatidylcholine. At least there are no other phospholipids that could compete for absorption and so on.
  • Nutrasal brand has polyenyl-phosphatidylcholine. According to ChatGPT, that means it’s predominantly PUFA. Except in practice not really if you look at the nutrition label. If you look at the page, they brag about its 1,2 DLPC content because of membrane fluidity and whatever the fuck.
• https://store.biopureus.com/products/biopure-liposorb%C2%AE?variant=39655926726845 $70 24x650 = 222mg/ $.
  • 650mg of PC per tsp. That probably means only 100mg of choline which is definitely more expensive than Nutrasal.
  • The label does not include fat, which makes me wonder if that’s just extra on the other things or if it’s from the PC. In any case, considering it’s derived from soy… I’m skeptical. It’s mostly linoleic acid (52%+ (just like Nutrasal said)), and them some oleic (15%) and palmitic (15%).
  • Looks like the same exact thing: https://www.quicksilverscientific.com/all-products/pure-pc-micellized/ tiny little liposomes. = 283mg/$

Liposome #

I think PC itself can be a liposome for other things, but apparently as a supplement, PC being liposomal might be very important. There’s a handful out there

• Effects of Linoleic Acid Position in Phosphatidylcholines and Cholesterol Addition on Their Rates of Peroxidation in Unilamellar Liposomes
  • Cholesterol incorporation into liposomes suppresses peroxidation.