yana-notes

TSC

2022-05-16: reference:

Tuberous Sclerosis protein #

Is a GAP of Rheb, thus an activator of mTORC1. Forms a TSC1-TSC2 complex, and the latter is the target of phosphorylation. This pic says it all:

    • Inhibited by AKT and S6K and a bajillion other things probably
    • Activated by AMPK and HIF-1α (via REDD1).
  • Tuberous Sclerosis Complex is a disorder with a high prevalence in Autism.