yana-notes

S6K

2022-04-13: reference:

S6K (Ribosomal protein S6 kinase 1 (RSK1)) #

Ribosomal protein S6 is involved in translation/phosphorylation regarding things like glucose homeostasis, cell size/proliferation.

  • It binds to membrane PIP3, just like AKT - they compete, you could say! S6K1 phosphorylates PDK1, dissociating it from PIP3, retarding its interaction with AKT. R
  • I’d say it’s most notably activated (phosphorylated) by:
    • mTORC1 (Thr389): induces a conformational change that allows phosphorylation of other sites that allow for S6K’s full activation. For proteins like:
      • PDK1 (Thr299)
      • Ser235/236
    • ERK.

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