mTORC1
2022-05-10: reference:
mTORC1 #
Activates translation of proteins; overall anabolism.
-
mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking
- Inhibition indeed attenuates it, and it requires NR2B. Did not mediate habitual response to sucrose.
- Yeah, alcohol promotes phosphorylation of NR2B in hippocampus/striatum
- Degraded Orbitofrontal Cortex white matter/reduced neuronal density are associated with alcohol-dependence - causative.
- Inhibition indeed attenuates it, and it requires NR2B. Did not mediate habitual response to sucrose.
- Promotes Neuropeptide Y expression.
-
A Central role for mTOR in lipid homeostasis
-
