Resveratrol

links: reference: Peat - Don’t be Conned by the Resveratrol Scam

• https://men-elite.com/2022/12/26/the-unexpected-downsides-of-resveratrol-as-an-aromatase-inhibitor/amp/ 10-18-2021

Resveratrol (3,5,4′-trihydroxystilbene) #

• Actually a natural plant Polyphenol
• Increases PGC-1α, ERR (it’s a phytoestrogen) SIRT1
  • Much of the research is sponsored by David Sinclair’s company, Sirtris. Many people say it doesn’t even affect sirtuins, with debunked research.
    • Ergo pretty much any research predicated on the assumption it activates SIRT1 is flawed. The radiotracer they used in studies activated it, not resveratrol itself.
  • Stanfield: The sirtuin activity is just from some stress response?
• Goitrogen.
• Reduces parvalbumin in the amygdala, but increases it in the hippocampus.
• MAO-A inhibitor.
• Interferes with insulin production
• Supposedly there’s a metaanalysis for reducing fat mass and increasing lean mass
• Delays growth plate fusion
• The estrogenic activity of resveratrol: a comprehensive review of in vitro and in vivo evidence and the potential for endocrine disruption I think it’s an AI but haven’t even read this
• Resveratrol ameliorates prenatal progestin exposure-induced autism-like behavior through ERβ activation
  • Eight kinds of clinically relevant progestins were used for prenatal exposure in pregnant dams, and the offspring showed decreased ERβ expression in the amygdala with autism-like behavior
• Inhibits mTOR and reduces TMAO
• Resveratrol as a Multifunctional Topical Hypopigmenting Agent for Skin!
  • Direct and indirect Tyrosinase inhibitor. Protects keratinocytes from oxidation.
  • has a rescuing effect on the stemness of interfollicular epidermal cells that can repair signs of photoaging in the melasma, a typical pigmentary skin disorder