Glutathione

links: reference: 10-19-2021

Glutathione (γ-glutamyl-Cysteinyl-Glycine) #

A triPeptide. Its oxidized form is Glutathione Disulfide, which forms a disfulfide bond between two GSHs at the thiol ($\ce{-SH}$, hence GSH, into $\ce{G-S-S-G}$.)

• The most abundant intracellular Antioxidant. Levels decline during aging, along with glycine and cysteine.

  • It seems that the likely weak link in the glutathione synthesis process is not cysteine. Instead, it may be the nutrients B6, B12, Folate, and Glycine.

• Chelates intracellular copper.

• https://www.youtube.com/watch?v=DBlQU-4P7Q8&t=1410s

  • Haidut: In people with healthier metabolisms, their levels of reduced glutathione is higher, because they aren’t dealing with reactive oxygen species etc.. Supplementing reduced glutathione isn’t a good idea, because it can shift the ratio of oxidized:reduced glutathione, which is a biomarker of redox status (balance between oxidants and antioxidants; reduction is the addition of an electron). Shifting the redox state towards reduction will reduce glucose metabolism.

• Lots of flack on glutathione: https://raypeatforum.com/community/threads/pyrucet-liquid-ethyl-pyruvate-aceatoacetate-mix.27487/

• Glutathione 101, Part 1: Cysteine Misbehaves, But Glutathione Saves (Masterjohn)

  • Cells keep concentrations of cysteine to the minimum.

• Anti-melanogenic since it inactivates Tyrosinase via binding to its copper-containing active site.