Androsterone
links: Steroid Hormones Neurosteroid reference:
Androsterone (3α-hydroxy-5α-androstan-17-one) (1-DHEA) #
Made by both testicles and adrenals.
-
https://men-elite.com/2018/11/09/androsterone-review-my-unbiased-unpayed-for-review-of-androsterone/
- Increases Insulin Sensitivity. Increases BDNF; neuroprotective. Vasorelaxant and anti-convulsant. Anti-Adrenaline, Cortisol, Prolactin, pro-Dopamine.
- Amongst other positives: increases temperature, energy and altertness (despite the GABAergic effects)
-
https://raypeatforum.com/community/threads/androsterone-liquid-androsterone-for-lab-r-d.12614/
- Androgen with a potency 1/7 that of testosterone.
- Precursor to DHT via the androgen backdoor pathway.
- GABA-A PAM. Stronger agonist than progesterone.
- Pro-hormone for DHT and Androstadienone.
- Pro-thyroid, pro-metabolic, brain protective, sedative, promotes insulin sensitivity, anti-estrogenic, convulsant, adrenaline, cortisol, cancer, depressant, etc.
- Thyroid manifests its effects though downstream hormones like this
- With a 1:1 or 1:3 ratio to DHEA, it’s highly anabolic. 1:1 had no plateau effect at high doses. Adding pregnenolone to the mix would only help. R
-
The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone
- Induces SHP
Supplementation #
- Shutdown at 12mg HED daily.
- https://www.adooq.com/androsterone.html 100mg for $40; 500mg for $160
-
https://supremelabsusa.com/product/1-andro-raw-powder/ $18g for 1g of 1-Andro. Which isn’t exactly the same thing.
- Said people take 200-600 mg/day, basically as a non-aromatizing non-DHT TRT. Idealabs: 240x1mg - $30 (actually a good deal?) Physiological doses are under 10mg a day. Studies have used hundreds and didn’t negatively affect the HPTA. FSH and LH remain the same. Stick to under 15mg, though. Not much of a reason to go above 5mg per dose, either. 3 weeks on, 1 week off.
- 2mg-3mg should be able to inhibit Aromatase by more than 90%?