Adenosine A1

2022-01-25 links: Adenosine Receptor reference:

Apparently antagonism essentially amounts to: Caffeine tolerance/addiction/withdrawal, some locomotive effects, and some euphoric/andrenergic effects,
The most abundant Adenosine Receptor. Gi-coupled.
A1AR reduces Dopamine and GABA.
- Adenosine suppresses the response of neurons to gaba in the superficial laminae of the rat spinal dorsal horn
  - The suppression of adenosine on GABA currents is mediated by A1A receptor and through a Ca(2+)-independent Protein Kinase C transduction pathway.
Inhibits wake-promoting Cholinergic neurons in the Basal Forebrain.
Activtion in the prefrontal cortex decreases Acetylcholine release in the Pontine Reticular Formation
A1 Adenosine Receptor Partial Agonists and Allosteric Modulators: Advancing Toward the Clinic? #

yana-notes