Protein Kinase C
2022-04-08: reference:
Protein Kinase C #
Phosphorylizes a protein using ATP. Can become persistently active if its regulatory and catalytic domain are proteolyzed from eachother. (There are isoforms without a regulatory domain.)
- DAG-requiring isoforms localize and bind to membrane Diacylglycerol.
- Requires DAG, Ca2+, and phospholipid for activation - “conventional”
- Protein Kinase Cα (PRKCA)
- Protein Kinase Cβ1 (PRKCB)
- Protein Kinase Cβ2 (PRKCB)
- Protein Kinase Cγ (PRKCG)
- DAG but not Ca2+ for activation - “novel”
- Protein Kinase Cδ (PRKCD)
- PKC-ε (PRKCE)
- PKC-η (PRKCH)
- PKC-θ (PRKCQ)
- Neither Ca2+ nor DAG for activation (requires Phosphatidylserine) - “atypical”
- PKC-ι (PRKCI) (AKA PKCλ?)
- Protein Kinase Cζ (PRKCZ)