ISRIB

2022-01-12 links: reference: https://scienceofparkinsons.com/2021/04/24/isrib/

ISRIB (Integrated Stress response inhibitor) #

• People develop problems with it. Some people recommend against it quite strongly due to it causing autism-like symptoms (due to GABA agonism?) People have been hospitalized from cardiovascular effects.
• Its purpose is to inhibit general translation (synthesis of proteins of all kinds)
• Basically. it converges on the phosphorylation→activation of eIF2α. So I guess the ‘Integrated stress response’ is just an abstraction in that way, but I’m sure there’s more to it. There are 4 kinases that do this, and each are induced by their own naughty things:
  • PERK
  • HRI
  • GCN2
  • PKR