Thyroxine-Binding Globulin

links: reference: https://en.wikipedia.org/wiki/Thyroxine-binding_globulin 4-28-2021

Thyroxine-Binding Globulin (TBG) #

A transport protein responsible for carrying T4 and T3 in the bloodstream. It does this along with trabsthyretin and serum Albumin, but it has the highest affinity. Synthesized primarily in the Liver.

• PUFAs can bind to it, since it has an affinity for unsaturated molecules.

• In comparison with humans, rodents are highly sensitive to goitrogenic treatment, because of a shorter plasma T4 half-life (12–24 h) in rats than in humans (5–9 days), which derives from the absence of high-affinity Thyroxine-Binding Globulin in rats that is present in humans.

• Testosterone inhibits synthesis of Thyroxine-Binding Globulin, while Estradiol stimulates it. R