Pyruvate

links: reference:

• https://raypeatforum.com/community/threads/pyrucet-liquid-ethyl-pyruvate-aceatoacetate-mix.27487/ - an actual fuckton of references. Does haidut just read the title or does he actually verify all of these? 6-3-2021

Pyruvate #

Considering pyruvate dehydrogenase is the rate-limited step in mitochondrial respiration, supplementing pyruvate can reap many benefits by increasing it.

• Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner.
  • For Astrocytes, I wonder what this means? Could it possibly make them more aerobic? Let’s read.
  • We examined the effects of excess exogenous pyruvate on intracellular LDH activity, extracellular acidification rates (ECARs) as a measure of lactate production, and hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion rates
  • Highly dependent on pyruvate influx, functinally mediated by MCT1.
• Pyruvate prevents the inhibition of the long-term potentiation induced by amyloid-β through protein phosphatase 2A inactivation
  • Nuff said. Pyruvate (but not lactate) prevents Amyloid β-induced PP2A activation and (just as a consequence?) Amyloid β block of CAMK II autophosphorylation
• Pyruvate and L-Lactate strongly counteracted the deep decrease in the neuronal ATP content induced by NMDA. The strong accumulation of extracellular glutamate which was found in both sham and NMDA-treated cultures was markedly decreased by pyruvate. R

Supplementation #

• Calcium pyruvate: a half life of ~5hr.

Pyrucet #

30x25 drops, $35

• 500mg ethyl acetoacetate
  • Causes Glutathione to plummet.
• 500mg ethyl pyruvate
  • 3-4hr half life. But its effects can last much longer. 10 drops, I suppose? 200mg pyruvate. Haidut says mixing it 1:1 with ethanol greatly increases (topical) effectiveness and half-life.
• Crashes your FAO. But raising of the liver metabolism will promote Glucuronidation, which is the healthiest way to get rid of body fat. Helps with joint/tendon pain.