CAMK II
2022-04-19: reference:
CAMK II #
(Auto)phosphorylation
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- CAMK2A is heterohexameric. After Ca (4 max) or Calmodulin binding, it conforms in such a way that opens its catalytic domains. It takes phosphate from ATP and adds it to Ca2+/Calmodulin - ‘autophosphorylation’ of the neighboring subunits. It becomes persistently active and “autonomous” after this and does not require Ca2+-Calmodulin.
- I believe this happens at Thr286
Targets #
- Activates Spinophilin, Ras-activating proteins (SYNGAP etc), Kalirin-7, CAMKK, ERK
Plasticity #
- As stated on the page, it can induce LTP or LTD at AMPAR at Ser567 and Ser831 respectively. This is basically determined ultimately by calcium dynamics: @Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection (Coultrap et al. 2014).
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Sensitivity of CaMK II to the frequency of Ca2+ Oscillations
- CaMK II can act as a frequency decoder of Ca2+ oscillations in vitro… After the threshld for kinase activation is reached an some subunits of the enzyme become autophosphorylated, the response of the kinase to low-frequency stimuli is increased.
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Sensitivity of CaMK II to the frequency of Ca2+ Oscillations
- αCamK II binds NR2 subunits to the NMDAR.
- CAMK II -> (unclear how? 2013) RhoA -> Actin reorganization -> Transient spine enlargement