Phenethylamine

links: Neurotransmitter reference:

• https://www.reddit.com/r/Nootropics/comments/mmf975/2phenylethylamine_pea_ameliorates/
  • Pretty sure it’s fucked 5-4-2021

Phenethylamine (PEA) #

Monoamine alkaloid and trace Amine. Made from Phenylalanine with AADC. CNS stimulant. Activates PPAR-α

• Like an amphetamine, releases noradrenaline and dopamine. Induces acetylcholine release via a glutamate-mediated mechanism.
• TAAR1 agonism and VMAT2 inhibition.
• Can feel better than cocaine and make you psychotic when MAO-B is inhibited, since it preferentially degrades PEA.
  • https://www.nature.com/articles/npp2009118
    • “MAO B KO mice displayed higher PEA levels in the frontal cortex (MAO B KO/WT ratio: 4.4; F(1,11)=145.44, P<0.001), striatum (MAO B KO/WT ratio: 11.5; F(1,11)=55.20, P<0.001), hippocampus (MAO B KO/WT ratio: 2.6; F(1,11)=20.94, P<0.001), thalamus (MAO B KO/WT ratio: 1.9; F(1,11)=7.42, P<0.05), and cerebellum (MAO B KO/WT ratio: 3.7; F(1,11)=11.67, P<0.01)”
  • Yeah; I’ve seen multiple people on reddit seeing it feels better than meth, heroin, or cocaine. But can lead to stroke, hypertension, brain damage, etc. in higher doses.