Forskolin

links: Nootropics reference: 4-24-2021

Forskolin #

• Significantly upregulates Tyrosine Hydroxylase and concentrations of cAMP, via Adenosine Receptors. R
  • Its cAMP modulation can increase formation of Estrogen? R
• Induces upregulation and supersensitivty of D2 receptors
  • Increases Tyrosine Hydroxylase and dopamine in hypothalamus
  • https://pubmed.ncbi.nlm.nih.gov/7851491/
  • Increases Dopamine release R
• D1 antagonism R
• Increases Luteinizing Hormone? This does seem to lead to an increase in testosterone
• Increases UCP1 (Thermogenin) and thermogenesis R
• Upregulates Acetylcholinesterase expression
• Leads to the production of the active form of hormone-sensitive lipase: HSL is directly involved in the mobilization of trigylceride stores in adipose tissues, releasing free fatty acids to be used within the body.
• Increases vasodilation
• 50mg daily resulted in 4.14% Body Fat loss and 16% increase in testosterone after 12 weeks. R
• Helps with asthma, glaucoma and heart function.
• Does not affect choline. R
• Upregulates Acetylcholinesterase expression. R

Supplementation #

25-50mg of pure forskolin orally seems to be a standard dose. (10g bag for 50mg/day lasts 200 days) Can lead to liver toxicity if not pure, since the herb it’s dervied from is a known hepatotoxin.