Curcumin

links: Nootropics reference:

• Uhhh is it a meme? https://reeserichardson.blog/2024/01/30/the-king-of-curcumin-a-case-study-in-the-consequences-of-large-scale-research-fraud/ 5-1-2021

Curcumin #

• Free radical scavenger and iron chelator. The primary bioactive substance in tumeric (which tastes pretty bad and might be a 5-AR inhibitor)… it seems curcumin inhibits it as well.
• Inhibits MAO.
• Potent inhibitor of TGF-β.
• Downregulates Estrogen Receptors activity, improves Insulin Sensitivity and Liver function.
• Reduces serum lipids and Uric Acid concentration and Liver steatosis. R
• Potent PPAR-γ agonist.
• A p300/CREB-binding protein-speific inhibitor of acetyltransferase.
• Increases HDAC2 but inhibits 1, 3, 4, 8.

Chelation #

• Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation
  • Destabilizes the endoplasmic reticulum, and secondarily Lysosomes, increasing autophagy/mitophagy and subsequent apoptosis.

Supplementation #

Piperine/black pepper increases the absorption of tumeric pills by like 20x.