AhR

2023-11-05:

AhR (Aryl Hydrocarbon Receptor) #

• Transcription factor. After ligand binding, such as TCDD, it translocates to the nucleus and dimerizes with ARNT (AhR nuclear translocator)
  • TCDD is a potent agonist of it. It was a ‘contaminant’ in Agent Orange, but still a significant amount. It’s very toxic and carcinogenic.
• Obesogenic and lowers bile acid secretion.
  • Increases HMG-CoA Reductase, but blocks CYP7A1/27A1, and activates ASBT. So more cholesterol, less bile. Because fuck you.
  • Increases CYP1B1, PPAR-α target genes, SCD1, and Osteopontin.
• B12 and Folate antagonize its activity.
• Polyphenols like Apigenin and Luteolin are potent suppressors of its activity.