ASBT

2023-11-05:

ASBT (SLC10A2) (apical sodium-dependent bile acid transporter) #

AKA ISBT (ileal).

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  • Specifically, OSTα/β brings it across the basolateral area membrane, which then goes to the portal vein proper.
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    • OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids
• The whole FIAB canon of nuclear receptors promtes it: RXR, PPARα, RAR, SREBP, SHP, as well as FGF19→JNK→c-jun/c-fos, etc.:
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    • https://www.researchgate.net/figure/The-progress-in-regulation-mechanism-of-ASBT_fig1_346059020