yana-notes

Alzheimer's

links: reference:

Alzheimer’s #

  • Can have excess DHEA
  • Retinoic acid as a therapeutic option in Alzheimer’s disease: a focus on cholinergic restoration
    • Over 70% of energy prouced in Neurons is utilized for restoration of their membrane potentials, after depolarization (i.e. Mg2+ displacement -> Ca2+ influx) takes place with a frequency of 10-50 Hz.
  • Type 1: Inflammatory (caused by ongoing inflamation from molecules like NF-κB)
  • Type 2: Atrophic (caused by suboptimal nutrition, hormones, neurotrophins)
  • Type 3: Glycotoxic (caused by diabetes)
  • Type 4: Toxic
  • Type 5: Vascular
  • Type 6: Traumatic (physical damage)