Oxytocin
9-7-2021 links: reference:
Oxytocin #
- Exposure to exogenous oxytocin prenatal/in early life disrupts the development of the system. Pitocin is a heavily abused synthetic oxytocin given to women to induce/augment labour, and is highly linked with postnatal depression and (when used during labor) the incidence of Autism in offspring.
- Oxytocin has been shown to promote ethnocentrism and preference for emotional bonding/preference for familiar people/objects.
- OT KO mice have reduced social recognition, and central OT administration into the amygdala restores social cognition. In the DHS model, a loss of OT-containing cells in the hypothalamus as well as a loss of OT projections towards the amygdala is associated with an abnormal social behavior.
- In healthy controls OT increases gaze to the eye region of the face, and attenuates amygdala response to emotional faces regardless of valence. Intranasal administration of OT specifically improves recognition memory for faces, but not for non-social stimuli in healthy humans R.
- Oxytocin: An Evolutionary Framework
- Inhibits CRH release
- α2A antagonist in the Vagus Nerve.
- Abused and socially defeated women have permanently dramatically elevated levels of oxytocin.