Tryptophan Hydroxylase

2022-02-18 links: Enzyme reference:

Tryptophan Hydroxylase (TPH) #

• TPH1 in the brain, TPH2 in the gut lining. The latter produces 90-95% of serotonin in the body. Catalyzes Tryptophan -> 5-HTP.
• Raised by stress, social defeat, trauma, submission, etc. R
  • We previously reported that chronic glucocorticoid exposure is anxiogenic and increases rat Tryptophan Hydroxylase mRNA expression… increased TPH2 protein expression in the dorsal and ventral part of the Dorsal Raphe Nucleus. Stress-induced TPH2 activity in the DRD/DRC furthermore predicted TPH2 activity in the amygdala and in the caudal pontine reticular nucleus (PnC), while serotonin synthesis in the PnC was strongly correlated with the maximum startle response. R
• Mice with ablated Tph fed an obesogenic diet had reduced weight gain, body fat, lowering fastinf glucose/insulin and protection from NAFLD.