yana-notes

Thyroid Supplementation

links: reference:

Thyroid Supplementation #

  • https://hormetheus.com/thyroid1/

    • Hypothyroidism is inadequate levels of actino of T3 - usually the gland is functioning perfectly, but T4->T3 Conversion or peripheral thyroid hormone resistance, or inadequate TSH.
      • Indeed, this is why T4 monotherapy is suboptimal.
      • Peripheral thyroid hormone resistance is something like poor balance of Deiodinase expression, like Type III in favor if II/I.
    • After supplementing, it’s possible for the thyroid to improve functioning.
      • rT3 has been depleted, mitochondrial activity/size/density improved, and issues with thyroid sensitivity and intracellular regulation of deiodinase enzymes (which cannot be measured) have been restored.
      • Sometimes this remains true even while free T3/T4 return to pretreatment levels, due to aforementioned changes in deiodinase expression, perhaps mitochondrial genetics/size/density, etc.
    • Short-term T3 monotherapy is used to permanently reverse thyroid resistance.
      • Dosages often need to be escalated in a successive fashion over the course of 6–8 weeks until a stable dosage is found and maintained. However, because of interindividual differences, the target dosage can range anywhere from 50mcg to 150mcg T3 per day, administered in 4–5 divided doses
      • Not good in the long-term: many tissues regulate their T4/T3 ratios independently (e.g. the brain will have a different ratio of T4 and T3 compared to the adrenal glands or muscle tissue). Therefore, on a T3-only regimen, it is likely that some tissues will be exposed to unphysiological local ratios of T4 and T3 and therefore some tissues might be in a state of thyroid excess while others might be in a state of thyroid deficiency.
    • While thyroid hormones set the “idle” for the system, Cortisol is the gas pedal. Lack of either hormone can result in a state of hypometabolism.
    • if the dosage is too high, paradoxically, this makes weight loss harder because high levels of thyroid hormones lead to a high turnover in plasma nutrients, which are often depleted faster than they can be replenished. Whenver nutrients fall (esp. glucose), the hypothalamus senses this. The resulting hypoglycemia then tends to make people ravenous. During these bouts of intense hunger, many people are quite prone to overeating.
    • Note: Whenever dosages of thyroid hormones are increased, Aromatase expression increases as well!. This often causes levels of estradiol to rise to high levels. Furthermore, thyroid hormones directly regulate the genetic promoter of SHBG, which often increases to high levels whenever thyroid hormone stimulation is excessive. Therefore, it is prudent to measure levels of sex hormones around 1–2 months after changing thyroid treatment protocol.
    • Realize that CFS and “fibromyalgia” are quite often simply a state of “starvation-mode” turned on. This is mostly a hormonal and mitochondrial issue induced by a long-term hypometabolic state (e.g. Hashimoto, long-standing hypothyroidism, chronic caloric restriction and dieting, anorexia nervosa, celiac disease, etc.), during which cellular gene expression and mitochondrial activity, and density change. This state of hypometabolism can be reversed by antidiabetic drugs, or even better, metreLeptin. T3 only helps symptomatically.

  • T4’s half-life in the body is 2 weeks, so the effect is accumulative. If you get the desired effects within that time, dose should probably be reduced.

  • An overdose can lead to things like insomnia… Sleep

  • The grerater the hypothyroidism, the slower one should start.

  • If you have adequate cholesterol (>200) and your temperature doesn’t increase after thyroid supplementation, somet

  • With inadequate levels of cortisol, or sometimes excessive levels, pooling can occur, which is when fT3 rises without entering the cells. https://stopthethyroidmadness.com/pooling/

  • During the first week or two, there’s usually an intensification of the effect of adrenaline/cortisol, which obvs increases BPM, but not always temp? This is due to the body having to adjust to the increased metabolic rate.

    • Thyroid supplementation does stimulate the HPA Axis at the hypothalamus and pituitary, leading to hypertrophy. Over weeks-months, Cortisol levels should increase.

  • If it decreases your heart rate (and you feel exhausted the day after taking it at night), it could be due to a reduction in adrenaline and/or cortisol.

  • If it increases your pulse, but decreases your temp, then this may be a stress response - cortisol/adrenaline is catabolizing the tissue to get more energy, and lowering the temp to conserve it.

  • Take multiple readings with digital thermometers. Stop only when it doesn’t go up on successive readings. Some people are bullish on armpit but it’s 0.5°C lower than oral.

  • You can use an oximeter to measure spO2 (Samsung has had it on the phone since Galaxy S5)

  • Synthetic thyroxine raises Histamine and lower DAO and MAO. There was also an increase in serotonin, and glutamate. What the?? R

NDT #

This leads to a sustained-release effect; a dose only once or twice a day is needed.

  • NDT may not show benefits until a month or so.
  • 30mcg NDT = 1/2 grain?
    • 4 grains of NDT is basically a full replacement dose, with regards to what we normally produce, 70% of which being T4.
  • Also contains stuff like T2, Calcitonin, iodine, and thyroglobulin. The Tg bestows a sustained-release effect.

Dosing, etc. #

  • One grain = 40mcg T4 + 10mcg T3.
  • Cynomel: 25mcg T3
  • One cynoplus tablet = 3 grains = 30mcg T3 and 120mcg T4.
  • Take it with food.

  • Between 1:3 and 1:4 T3:T4.

    • The body secretes it in a ratio of 1:6-1:8.

  • The whole process of fully transitioning into T4 might take on the order of 2–3 months (e.g. 60mcg T3 split into 4 daily doses (T3-only treatment) → adding 25mcg T4 (week 1 of transitioning) → 45mcg T3 split into 4 daily doses + 25mcg T4 once in the morning (week 2–4)→ 25 mcg T3 split into 3 daily doses + 50mcg T4 once in the morning (week 4–6) → continue until the desired ratio is reached. However, it should be noted that protocols need to be highly individualized and mostly guided by signs (e.g. body temperature, heart rate, blood pressure, circadian variations thereof, etc.) and symptoms.)

  • Principle: Starting with 25% of the presumed target dose and then gradually increasing the dosage over a 2 month period. Implementation: Starting out with 0.25 grains of NDT (or 20–25% of the presumed target dose) → increase by 0.25 grains every 14 days until the average target dose of 1.25 or 1.5 grains/day is reached (about 0.25 grains less in the summer).

  • “An eighth of a tablet [twice a day] of cynoplus/cynomel is a good starting dose.” (15mcg T4, 3.75mcg T3) “Half a grain of armor, or about 30mcg of T4 and 7.5mcg of T3 is a common starting dose.”

  • The body makes ~4mcg of T3 in an hour. Don’t take >4mcg of T3 at once. Spread it throughout the day.

    • Armour has changed owners and I believe formulations throughout the years. Ray Peat thinks it’s sus or something. ‘CIA changed armour thyroid’

  • “When I used only Cytomel, any little stress would make me suddenly hypothyroid, and my heart would stop several times in a minute; when I started using some thyroid, USP, that contained both T4 and T3 it stopped happening.”

Timing #

  • NDT, T4, and especially T3 are better utilized taken in the evening, in order to match its fluctuation with the circadian rhythm. RPF
  • T3 is only weakly bound to plasma proteins and has a half-life of just around 15–20 hours after administration. Therefore, to achieve stable levels of fT3 in the plasma and peripheral tissues:
    • T3: 4x daily.
    • T4/T3 combination: 2–3x daily
    • NDT: 2x daily on NDT treatment
  • T3 should not be taken 3-4 hours before bed, or else it would probably disrupt sleep architecture.

Source #

  • Just realized the making of liquid supplements like Haidut is quite a good idea to pre-measure the microdoses. It’s in SFA esters and ethanol.
  • 4μg/drop (.05mL) = .08mg/mL = 2.4mg for a 30mL bottle, lol. Most sources say it’s something like 1-10mg/mL. Good enough for me.
  • PurplePandaLabs 3,5,3’-Triiodothyronine: 1g for $25 lol. (1mil mcg lmao)
    • According to random steroid websites, half life is 2+ years. Buut I’ll have an absolute pile so if it merely degrades in quality I can just double the concentration/dose.
  • PPL: T4 Euthyrox (Levothyroxine; simply synthetic T4) 100mcgx50 - $41.
    • Euthyrox has bad reviews? But T4 monotherapy sucks especially compared to NDT or something so
  • PPL: T3 Tiromel tablets 25mcgx100 - $32. Seems legit; $16 100x25mcg also has cynomel: https://farmaciasdelnino.mx/eng/item/2489/cynoplus-levothyroxine-liothyronine-30-mcg-120mcg-50-tab

Protocol #

Backlinks

  • No backlinks found

Interactive Graph