TSH

links: Hormones Thyroid reference: 4-11-2021

TSH #

Produced in the Pituitary Gland.

• Lowered by the presence of T4.

• Produced in the pituitary gland. (Hypothyroidism causes overactivity of it)

• Increases inflammation and interleukin-18, and seems to be correlated with Estrogen and Cortisol. R

• TSH Activates Macrophage Inflammation by G13- and G15-dependent Pathways

  • Induces phosphorylation of p38 and activates an inhibitor of NF-κB (IκB) in macrophages.
  • The present study demonstrate that TSH activates macrophage inflammation by the G13/ERK–P38/Rho GTPase and G15/phospholipase C (PLC)/protein kinases C (PKCs)/IκB pathways.

• Increases C-Reactive Protein

• TSH is also responsible for stimulating the body’s production of iodine transport molecules - the sodium-iodide symporter NIS. So, a huge elevation in TSH during iodine supplementation is to be expected. I think I read somewhere it can take like 6 months for this to wear off? Maybe that’s because it’s a halogen?

Labs #

• 0.3-1 is ideal. But this alone isn’t everything. Having TSH within this range does not preclude hypothyroidism. (4/12 I got 1.130)
• I think you want it low, because amongst other things, it implies your T3/T4 levels are in check/high - otherwise, TSH would be high. T4->T3 conversion could still be low regardless, though.