Sirtuin
2021-12-03 links: reference:
Sirtuin #
Very important and ancient signaling protein. Class III of of the HDACs.
- Dependent on NAD+ to maintain cellular health and to turn it into Niacinamide.
- SIRT = human gene; Sirt = mice
- Sirt inhibitors lower FAO
| Class | Gene | Location | Activity | Function |
|---|---|---|---|---|
| I | SIRT1 | Nucleus, Cytoplasm | Deacetylase | Metabolism, inflammation |
| I | SIRT2 | Nucleus, Cytoplasm | Deacetylase | Cell cycle, tumirogenesis |
| I | SIRT3 | Mitochondria | Deacetylase | Metabolism |
| II | SIRT4 | Mitochondria | ADP-ribosyl transferase | Insulin secretion |
| III | SIRT5 | Mitochondria | Deacetylase, dealonylase, desuccinylase | Ammonia detoxification |
| IV | SIRT6 | Nucleus | Demyristoylase, Depalmitoylase, ADP-ribosyltransferase, deacetylase | DNA repair, metabolism, TNF secretion |
| IV | SIRT7 | Nucleolus | Deacetylase | rRNA transcription |
PGC1a activates sirt 1 and sirt 6, NRF2 activates sirt 1 and sirt 6, PPARA/PPARG activate sirt 1 and sirt 6, irisin and AMPK activate sirt 1, but can stimulate NRF2, so may have activate sirt 6. PQQ activates PGC-1α and Irisin and is proven to activate sirt 1 but should also activate sirt 6, Vit d3 has positive effects on pgc1a, irisin, ampk, nrf2, and has been shown to activate sirt 1 and sirt 6, pinealon increases irisin, nrf2, PPARA/PPARG so should be a good activator of sirt1 and sirt 6, TUDCA has shown to enhance sirt 6, Carnosic acid activates NRF2 and has been shown to activate sirt1 but should activate sirt 6 too.