Retinoic Acid

links: Isotretinoin reference:

6-5-2021

Retinoic Acid #

Metabolite of Retinol. Sunlight converts Retinol stored in the skin to RA, causing sunburn.

• Significantly decreases progesterone receptor gene transcription. R
• Can cure Dairy (milk?) allergies? RPF
• Retinoic acid induces IGF-II expression in a neuroblastoma cell line https://www.reddit.com/r/AccutaneRecovery/comments/o8d2km/post_accutane_syndrome_is_likely_a_dysfunction/
• 5-fold increases in expresions of Cytochrome P450 and StAR, and 50-fold inrease in 3β-HSD in glial cells.
• RA significantly decreases Progesterone receptor gene transcription.

Receptor #

• There is the Vitamin A receptor (STRA6(Stimulated by retinoic acid 6)) is a transmembrane cell-surface receptor for retinol-binding protein. (Retinol binds to RBP and transthyretin) taking it into the cell. CRBP (cellular retinol binding proteins) stabilize it within the cell. - Then, it reaches RXR/RAR which are both nuclear receptors.
• Retinol-binding protein also transports Thyroid hormone.